Title : Pharmaceutical Applications of Nanotechnologies
Speaker : Prof. Yu-Kyoung Oh (College of Pharmacy, SNU)
Date & Time : 2012. 5. 16.
수요일 17:00
Where : 융대원 D-123
Abstract
Recently, the convergence of nanotechnologies to pharmaceutical sciences has drawn attentions. Nanotechnologies can be used for delivery of drugs, diagnostics, imaging agents, and design of nanomedical devices. Nanotechnologies have been applied to increase the solubility of poorly soluble drugs by increasing surface areas. In the market, NanocrystalTM technology has been applied to increase the solubility of immunosuppressant. Drug-encapsulated nanoparticles have been studied to control the release rates of drug in the body or to modulate the distribution of the drug in the body. In particular, the vasculature in tumor tissues is known to have leaky structure as compared to the vessels in normal tissues, and be more permeable to nanoparticles. The physiological property of tumor vasculature provided basis for the delivery of anticancer drug-loaded nanoparticles for enhanced tumor tissue accumulations. Theranostics is a new emerging class of nanomedicine carrying both therapeutics and diagnostics for detection of disease site in the body and targeted delivery of therapeutic drugs.
Nanoparticles for pharmaceutical applications can be divided depending on the sources such as lipid, polymer, inorganic, and biological materials. Lipid-based nanoparticles include liposomes, and solid-lipid nanoparticles. Until now, several nanoliposomal products are commercially available in the markets or in development. As compared to other nanoparticles, liposomes have advantages in that they can be easily degraded in the body by the natural degradation machineries such as lipases. Moreover, the cell membranes of human are composed of phospholipids, the main components of liposomes. By modulating the surface properties, liposomes can be used as cargoes of hydrophilic, hydrophobic, and charged drug molecules. One example of charged drug molecules is small interfering RNAs (siRNAs), which emerged as next generation pharmaceuticals in gene therapy field. Taking advantage of negative charges of siRNAs, cationic liposomes have been studied as in vivo delivery systems of nucleic acid therapeutics.
Solid-lipid nanoparticles with lipophilic components inside have been studied not only in pharmaceutical sciences but also in functional cosmetic delivery. Polymeric micelles with hydrophilic and hydrophobic moieties have been developed to encapsulate poorly soluble drugs in the hydrophobic core parts. Inorganic nanoparticles have been studied for diagnostics or magnetic field-guided external delivery of drugs.
In the near future, multifuncional nanoparticles would be more actively studied. As the name implies, multifunctional nanoparticles are the ones with additional properties such as stabilization, targeting, and penetration.
Education and Experience
· Ph.D. degree : College of Pharmacy, State University of New York at Buffalo, USA (1994 June)
· M.S. degree : College of Pharmacy, Seoul National University, Korea (1988 Feb.)
· B.S. degree : College of Pharmacy, Seoul National University, Korea (1986 Feb.)
· 1997 Sep. - 1998 Aug. : Patent examiner, Korea Intellectual Property Office, Korea
· 1999 Mar. - 2005 Aug. : College of Medicine, CHA University, Korea
· 2005 Sep. - 2009 Aug. : School of Life Sciences and Biotechnology, Korea University, Korea
· 2009 Sep. - Present : School of Pharmacy, Seoul National University, Korea
초청자 : 나노융합학과 Prof. Jan Lagerwall (연락처 : 031-888-9165, janlagerwall@snu.ac.kr)
