차세대융합기술연구원

Abstract

Nanoscopic delivery vehicles capable of encapsulating drug molecules and releasing them in response to external stimuli are of great interest due to implications in therapeutic applications. Micellar assemblies are promising scaffolds to overcome many of the problems faced with traditional chemotherapies because of their capacity for non-covalent, hydrophobic guest molecule binding. However, the stability of encapsulation with such selfassembled systems is limited during blood circulation because of an  undesirable escape of drug molecules. Thus, deliberate molecular design for stable encapsulation, targeting and triggered release is required. For this purpose, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/inter-chain crosslinking reaction. We can control the size of the nanogel from 10 nm to 200 nm and theses nanogels showed different release profiles depending on crosslinking in responsive to stimuli. Nanogels showed great stability to encapsulate hydrophobic guest and this model drug was only released inside cell. In addition, we can use surface modified nanogel with positive cell penetration peptide for binding protein and intracellular delivery. Hence, the reversible nanogel formation using self crosslinking polymers and the corresponding method of surface modification are a promising platform for creating polymer nanogels for a range of biomedical applications, from drug delivery to biosensing.

Education and Experience

· Ph.D. (Suparmolecular Chemistry) 2006, Yonsei University

· M.S. (Organic Chemistry) 2002, Yonsei University

· B.S. (Chemistry) 2000, Yonsei University

· 2011 - present : Research Assistant Professor, Department of Chemistry, Seoul National University

· 2007 -  2011 : Post Doctoral Researcher, Department of Chemistry, University of Massachusetts-Amherst